ParkinsonCanadaV1, Main, Exploration, bibRecord, 003B06

Neurodegenerative disorders in humans: the role of glutathione in oxidative stress-mediated neuronal death

Identifieur interne : 003B06 ( Main/Exploration ); précédent : 003B05; suivant : 003B07

Neurodegenerative disorders in humans: the role of glutathione in oxidative stress-mediated neuronal death

Auteurs : Jaswinder S. Bains [Canada] ; Christopher A. Shaw [Canada]

Source :

Brain Research Reviews [ 0165-0173 ] ; 1997.

RBID : ISTEX:C620F3FA61A696E7FCBB69BFD52E265BA5C3B615

Descripteurs français

Pascal (Inist)
- Article synthèse, Démence Alzheimer, Glutathion, Homme, Maladie dégénérative, Mort cellulaire, Neurotransmetteur, Parkinson maladie, Stress oxydatif, Sénescence.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Alzheimer disease, Cell death, Degenerative disease, Glutathione, Human, Neurotransmitter, Oxidative stress, Parkinson disease, Review, Senescence.

Abstract

Oxidative stress has been implicated in both normal aging and in various neurodegenerative disorders and may be a common mechanism underlying various forms of cell death including necrosis, apoptosis, and excitotoxicity. In this review, we develop the hypothesis that oxidative stress-mediated neuronal loss may be initiated by a decline in the antioxidant molecule glutathione (GSH). GSH plays multiple roles in the nervous system including free radical scavenger, redox modulator of ionotropic receptor activity, and possible neurotransmitter. GSH depletion can enhance oxidative stress and may also increase the levels of excitotoxic molecules; both types of action can initiate cell death in distinct neuronal populations. Evidence for a role of oxidative stress and diminished GSH status is presented for Lou Gehrig's disease (ALS), Parkinson's disease, and Alzheimer's disease. Potential links to the Guamanian variant of these diseases (ALS–PD complex) are discussed. In context to the above, we provide a GSH-depletion model of neurodegenerative disorders, suggest experimental verifications of this model, and propose potential therapeutic approaches for preventing or halting these diseases.

Url:

https://api-v5.istex.fr/document/C620F3FA61A696E7FCBB69BFD52E265BA5C3B615/fulltext/pdf

DOI: 10.1016/S0165-0173(97)00045-3

Affiliations:

Canada

Le document en format XML

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<front><div type="abstract" xml:lang="en">Oxidative stress has been implicated in both normal aging and in various neurodegenerative disorders and may be a common mechanism underlying various forms of cell death including necrosis, apoptosis, and excitotoxicity. In this review, we develop the hypothesis that oxidative stress-mediated neuronal loss may be initiated by a decline in the antioxidant molecule glutathione (GSH). GSH plays multiple roles in the nervous system including free radical scavenger, redox modulator of ionotropic receptor activity, and possible neurotransmitter. GSH depletion can enhance oxidative stress and may also increase the levels of excitotoxic molecules; both types of action can initiate cell death in distinct neuronal populations. Evidence for a role of oxidative stress and diminished GSH status is presented for Lou Gehrig's disease (ALS), Parkinson's disease, and Alzheimer's disease. Potential links to the Guamanian variant of these diseases (ALS–PD complex) are discussed. In context to the above, we provide a GSH-depletion model of neurodegenerative disorders, suggest experimental verifications of this model, and propose potential therapeutic approaches for preventing or halting these diseases.</div>
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La maladie de Parkinson au Canada (serveur d'exploration)

Neurodegenerative disorders in humans: the role of glutathione in oxidative stress-mediated neuronal death

Neurodegenerative disorders in humans: the role of glutathione in oxidative stress-mediated neuronal death

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	La maladie de Parkinson au Canada (serveur d'exploration)
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